Declining b-Cell Function Relative to Insulin SensitivityWith Escalating Oral Glucose Tolerance Test 2-h Glucose Concentrations in the Nondiabetic Through the Diabetic Range in Overweight Youth
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چکیده
RESEARCH DESIGN AND METHODS—A total of 147 overweight (BMI$85th percentile for age and sex) youth, aged 8 to,20 years, undertook three tests: 1) a 3-h hyperinsulinemiceuglycemic clamp; 2) a 2-h hyperglycemic clamp; and 3) a 2-h OGTT. Participants were categorically assigned to five groups according to their OGTT 2-h plasma glucose level, ranging from,120 to $200 mg/dL. b-Cell function relative to insulin sensitivity, assessed by clamp disposition index (DI) and oral disposition index (DIO), were compared among groups.
منابع مشابه
Declining β-Cell Function Relative to Insulin Sensitivity With Escalating OGTT 2-h Glucose Concentrations in the Nondiabetic Through the Diabetic Range in Overweight Youth
OBJECTIVE Overweight in youth is associated with the risk of developing type 2 diabetes. We hypothesized that β-cell function relative to insulin sensitivity decreases with increasing 2-h glucose levels based on an oral glucose tolerance test (OGTT) in overweight youth. RESEARCH DESIGN AND METHODS A total of 147 overweight (BMI ≥85th percentile for age and sex) youth, aged 8 to <20 years, under...
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متن کاملBeta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test.
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تاریخ انتشار 2011